The adverse effects reported most frequently with omeprazole have been gastrointestinal disturbances, in particular diarrhoea, constipation, abdominal pain, nausea and vomiting and flatulence. Skin rash, pruritus and urticaria have also been reported, usually resolving after discontinuation of treatment.
Central nervous system disorders reported so far include paresthesia, dizziness, lightheadedness and feeling faint, all of these usually resolved on cessation of therapy. Somnolence, insomnia and vertigo have been reported rarely. Reversible mental confusion, agitation, depression and hallucinations have occurred predominantly in severely ill patients.
Other adverse events reported rarely include arthralgia and myalgia, blurred vision, taste disturbances, peripheral oedema, hyponatremia, blood disorders including agranulocytosis, leucopenia, thrombocytopenia, pancytopenia, anaphylactic shock, malaise, fever bronchospasm, encephalopathy in patients with pre-existing severe liver disease, hepatitis with or without jaundice, rarely hepatic failure and interstitial nephritis which has resulted in acute renal failure.
Rare: Hypersensitivity reactions, Myalgia, Anaphylactic reaction, Erythema multiforma.